Abstract | BACKGROUND: METHOD: A review of publications in the National Library of Medicine and National Institutes of Health database was conducted in August 2009 using specific keyword search terms pertaining to subarachnoid hemorrhage and MAPKs. FINDINGS: There are nine in vitro studies and 17 in vivo studies published. Most of previous studies used MAPK inhibitors or their upstream molecule inhibitors, and showed that MAPK inhibitions prevented vasospasm. The MAPK cascade appears to interact with other signaling molecules, and MAPK may be an important final common pathway for the signaling transduction during cerebral vasospasm. However, the mechanism by which MAPK causes sustained vascular smooth muscle contraction remains unclear. In addition, the role of endogenous MAPK inhibitors, MAPK phosphatases, has not been investigated in cerebral vasospasm. CONCLUSIONS: The experimental data support the causative role of MAPK in cerebral vasospasm and warrant further research.
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Authors | Hidenori Suzuki, Yu Hasegawa, Kenji Kanamaru, John H Zhang |
Journal | Acta neurochirurgica. Supplement
(Acta Neurochir Suppl)
Vol. 110
Issue Pt 1
Pg. 133-9
( 2011)
ISSN: 0065-1419 [Print] Austria |
PMID | 21116928
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Mitogen-Activated Protein Kinases
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Topics |
- Animals
- Humans
- Mitogen-Activated Protein Kinases
(metabolism)
- Models, Biological
- PubMed
(statistics & numerical data)
- Signal Transduction
(physiology)
- Subarachnoid Hemorrhage
(complications)
- Vasospasm, Intracranial
(enzymology, etiology)
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