Highly effective generic adjuvant systems for orphan or poverty-related vaccines.

Abstract

Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.

• Authors: Mangala Rao, Kristina K Peachman, Qin Li, Gary R Matyas, Sathish B Shivachandra, Richard Borschel, Venee I Morthole, Carmen Fernandez-Prada, Carl R Alving, Venigalla B Rao
• Journal: Vaccine (Vaccine) Vol. 29 Issue 5 Pg. 873-7 (Jan 29 2011) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 21115053 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Adjuvants, Immunologic
• Anthrax Vaccines
• Antibodies, Bacterial
• Antibodies, Neutralizing
• Liposomes
• Aluminum Hydroxide

Topics

• Adjuvants, Immunologic (administration & dosage, adverse effects)
• Aluminum Hydroxide (administration & dosage, adverse effects)
• Animals
• Anthrax (prevention & control)
• Anthrax Vaccines (adverse effects, immunology)
• Antibodies, Bacterial (blood)
• Antibodies, Neutralizing (blood)
• Liposomes (administration & dosage, adverse effects)
• Macaca mulatta
• Primate Diseases (prevention & control)
• Survival Analysis