Abstract | PURPOSE: To investigate the possible association between cytomegalovirus (CMV) infection and Posner-Schlossman syndrome using PCR. To evaluate the clinical effect of valganciclovir treatment. PATIENTS AND METHODS: Patients with anterior uveitis associated with suspected Posner-Schlossman syndrome had their aqueous humor prospectively analyzed for viral deoxyribonucleic acid by HXFL4 gene detection using quantitative real-time PCR. RESULTS: Seven patients (two females and five males from 15 to 56 years old) with clinical signs of Posner-Schlossman syndrome (anterior nongranulomatous hypertensive uveitis with anterior chamber cells, central keratic precipitates, anisocoria, without iris atrophy) were tested. Examinations of the aqueous humor by polymerase chain reaction demonstrated CMV- DNA in five patients and were negative for other herpes viruses in all patients. Two patients were treated with oral antiviral therapy ( valganciclovir). Relapses occurred in all cases after cessation of therapy. DISCUSSION: Aqueous humor analysis by PCR is useful in differentiating between CMV and other herpes viruses and in making a positive etiological diagnosis in anterior hypertensive uveitis. Valganciclovir may be effective in treating CMV anterior uveitis, but its exact role should be determined in larger studies with a longer follow-up. CONCLUSION: Cytomegalovirus detection in aqueous humor using polymerase chain reaction is useful in the management of patients with Posner-Schlossman syndrome.
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Authors | C Rodier-Bonifas, P-L Cornut, G Billaud, B Lina, C Burillon, P Denis |
Journal | Journal francais d'ophtalmologie
(J Fr Ophtalmol)
Vol. 34
Issue 1
Pg. 24-9
(Jan 2011)
ISSN: 1773-0597 [Electronic] France |
Vernacular Title | Intérêt de la recherche du cytomégalovirus par polymerase chain reaction dans le syndrome de Posner-Schlossman. |
PMID | 21112125
(Publication Type: English Abstract, Journal Article)
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Copyright | Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
Topics |
- Adolescent
- Adult
- Biomedical Research
- Cytomegalovirus
(genetics, isolation & purification)
- Cytomegalovirus Infections
(virology)
- Female
- Glaucoma
(virology)
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Prospective Studies
- Syndrome
- Uveitis
(virology)
- Young Adult
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