The status of thrombophilic defects and non-O blood group as risk factors for gestational vascular complications among Tunisian women.

Abstract

AIMS:

Our objectives were to assess inherited thrombophilia and non-O blood group for the risk of gestational vascular complications among the Tunisian population.

METHODS:

This study comprised 203 test subjects with adverse pregnancy outcomes including recurrent pregnancy loss, intra-uterine growth retardation, pre-eclampsia and placental abruption. Each subgroup was matched with 100 controls and analyzed separately. All patients were evaluated for factor V Leiden, factor II G20210A mutations and for non-O blood group. Protein S, protein C and antithrombin levels were determined and deficiencies noted.

RESULTS:

The factor V Leiden mutation, non-O blood group and protein C deficiency had the highest incidences among patients both as a whole and in the 4 subgroups. The factor II G20210A mutation, protein S and antithrombin deficiencies were not statistically significant risk factors.

CONCLUSION:

Our results provide evidence for a significant association between the factor V mutation and placental abruption. Furthermore, we found that this and the non-O blood group independently increased the risk for intra-uterine growth retardation in our population.

• Authors: Sarra Klai, Najiba Fekih-Mrissa, Radhouen Rachdi, Nasredine Gritli
• Journal: Acta haematologica (Acta Haematol) Vol. 125 Issue 3 Pg. 115-20 ( 2011) ISSN: 1421-9662 [Electronic] Switzerland
• PMID: 21109732 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 S. Karger AG, Basel.

Chemical References

• Biomarkers
• Blood Group Antigens
• factor V Leiden
• Factor V
• Prothrombin

Topics

• Abruptio Placentae (etiology, genetics)
• Adult
• Biomarkers (blood)
• Blood Group Antigens (blood)
• Case-Control Studies
• Factor V (analysis)
• Female
• Fetal Growth Retardation (etiology)
• Humans
• Incidence
• Middle Aged
• Mutation
• Pregnancy
• Pregnancy Complications, Hematologic (epidemiology, etiology)
• Protein C Deficiency (complications)
• Prothrombin (analysis, genetics)
• Risk Factors
• Thrombophilia (diagnosis, epidemiology, etiology)
• Tunisia (epidemiology)