Abstract | PURPOSE: MATERIALS AND METHODS: In a recent 3 years, 63 patients (mean age, 60 years; range 26-81 years) with 64 RCCs were treated by RFA. The lesions had a diameter between 1.8 and 9.8 cm (average diameter, 3.1 cm). The indications for RFA treatment included chronic renal insufficiency (n = 10), presence of solitary kidney (n =3), bilateral renal carcinoma (BRCC) (n =2), advanced age (n =12), significant medical comorbidity (n =29) or refusal of conventional therapy (n =7). Tumors were treated by laparoscopy-assisted (n =41), open surgical (n =18) or percutaneous US guidance (n =4). Follow-up CEUS and contrast-enhanced CT were performed 1 month after treatment to assess the necrotic area. Technical success was defined as elimination of areas that enhanced at imaging within the entire tumor. RESULTS: On the 1-month CEUS and CT imaging after RFA, 62 of 64 tumors (96.9%) were successfully ablated with one session, and residual tumors were found in two RCCs. One of the two tumors was subjected to additional RFA treatment. We could not obtain a complete ablation in the other tumor of a patient with solitary kidney. The diagnostic concordance between the CEUS and 1-month follow-up CT was 100%. Sixty-one patients survived in the follow-up phase which ranged from 2 to 34 months. One patient with solitary kidney died of systemic disease progression and one patient was lost to follow-up. Of the 61 tumors without residual on both CT and CEUS after RFA, four had suspicious findings of recurrence on follow-up CEUS, and two of them were confirmed by subsequent CT examination. With CT as the reference imaging procedure in the assessment of renal tumor ablation, the sensitivity, specificity, positive predictive value, and negative predictive value of CEUS for detecting recurrence during follow-up were 100%, 96.6%, 50%, and 100%. CONCLUSION: Despite its limitation of false-positive value, CEUS is potentially effective in assessing the therapeutic response to RFA of RCC.
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Authors | Wen-Tao Kong, Wei-Wei Zhang, Hong-Qian Guo, Jun-Lan Qiu, Min Tang, Zhi-Min Jiang, Yi Shen, Xiao-Gong Li, Shi-Wei Zhang |
Journal | Abdominal imaging
(Abdom Imaging)
Vol. 36
Issue 3
Pg. 342-7
(Jun 2011)
ISSN: 1432-0509 [Electronic] United States |
PMID | 21107560
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Phospholipids
- contrast agent BR1
- Sulfur Hexafluoride
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Renal Cell
(diagnostic imaging, surgery)
- Catheter Ablation
- Contrast Media
- Female
- Humans
- Kidney Neoplasms
(diagnostic imaging, surgery)
- Male
- Middle Aged
- Phospholipids
- Sulfur Hexafluoride
- Tomography, X-Ray Computed
- Ultrasonography
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