Abstract |
A highly sensitive and selective electrochemical DNA signaling scheme, which identifies the point mutation existing in target DNA sequence, is developed based on the combination of label-free hairpin probe (HP)/ DNA endonuclease with zirconia (ZrO(2)) nanoparticle film, representing a promising screening platform for the accurate diagnosis of infections and genetic diseases as well as for environmental and forensic applications.
|
Authors | Rong Hu, Zai-Sheng Wu, Songbai Zhang, Guo-Li Shen, Ruqin Yu |
Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 47
Issue 4
Pg. 1294-6
(Jan 28 2011)
ISSN: 1364-548X [Electronic] England |
PMID | 21103482
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- DNA Probes
- DNA
- Zirconium
- zirconium oxide
|
Topics |
- DNA
(analysis)
- DNA Probes
(chemistry)
- Electrochemical Techniques
(methods)
- Inverted Repeat Sequences
- Metal Nanoparticles
(chemistry, ultrastructure)
- Polymorphism, Single Nucleotide
- Zirconium
(chemistry)
|