HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation.

Abstract
The present study was undertaken to examine changes in vascular ultrastructure of rats subjected to hypervitaminosis D with or without treatment with ethane-I-hydroxy-I, I-diphosphonate (EHDP). Five groups of rats were studied. Untreated rats were given 0.9% NaCl i.p. Sham-treated rats were given vehicle (corn oil). Treated rats were given ergocalciferol (75,000 IU i.p.) dissolved in vehicle with or without EHDP (5 mM/100 g body-weight i.p.). Rats which had been given ergocalciferol without EHDP developed hypercalcemia and demonstrated significant arterial calcinosis. A similar degree of calcinosis was not observed in rats given ergocalciferol with EHDP. EHDP appeared to inhibit arterial calcinosis; however, it did not affect plasma calcium levels. This suggests that EHDP might delay calcium influx into the cell and thereby prevent calcium overload. Our findings support the suggestion that EHDP therapy can be an effective treatment for the inhibition of dystrophic arterial calcinosis.
AuthorsJ G Kingma Jr, P E Roy
JournalJournal of experimental pathology (Oxford, England) (J Exp Pathol (Oxford)) Vol. 71 Issue 2 Pg. 145-53 (Apr 1990) ISSN: 0958-4625 [Print] England
PMID2109995 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ergocalciferols
  • Etidronic Acid
Topics
  • Animals
  • Aorta, Thoracic (drug effects, ultrastructure)
  • Aortic Diseases (chemically induced, pathology)
  • Calcinosis (chemically induced, pathology)
  • Ergocalciferols (administration & dosage)
  • Etidronic Acid (pharmacology)
  • Male
  • Microscopy, Electron
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: