[Immunoglobulin class and light chain type of oligoclonal bands in CSF in children with CNS infectious diseases].

Abstract

Agarose gel electrophoresis and immunofixation of CSF and serum from 16 patients aged from 1 day to 13 years with CNS infectious diseases (5 with purulent meningitis, 5 with aseptic meningitis, 4 with acute encephalitis, 1 with subdural empyema and 1 with SSPE) revealed oligoclonal IgG bands in 10 cases. In 4 cases, a high CSF/serum albumin ratio was recognized without an increase of IgG-index, probably representing a systemic immune response. Neither IgA nor IgM bands were recognized. IgG light chain was examined in 7 cases and IgG kappa bands predominated in 6 cases. IgG lambda bands predominance presented in only one case. Free IgG kappa or lambda chain was not found. These results suggested that the measurement of not only IgG-index but oligoclonal bands may have a diagnostic usefulness to know about local production of immunoglobulins in CSF.

• Authors: R Sakuta, K Hiyoshi, K Yanagida, Y Fujita, O Okubo, Y Utsumi
• Journal: No to hattatsu = Brain and development (No To Hattatsu) Vol. 22 Issue 2 Pg. 160-5 (Mar 1990) ISSN: 0029-0831 [Print] Japan
• PMID: 2109993 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin Light Chains
• Immunoglobulins

Topics

• Adolescent
• Central Nervous System Diseases (immunology)
• Cerebrospinal Fluid (immunology)
• Child
• Child, Preschool
• Humans
• Immunoglobulin Light Chains (analysis)
• Immunoglobulins (analysis)
• Infant
• Infant, Newborn
• Infections (immunology)