Abstract |
Lipid peroxidation was measured in 19 very low birth weight infants with respiratory distress syndrome by quantitating ethane and pentane in expired air during the first 5 days postnatally. Despite high levels of inspiratory oxygen, the ethane and pentane output was low within the first 24 hours; thereafter it increased up to 100 and 30 fold, respectively. On days 1 to 3 there was no detectable correlation between lipid peroxidation and fractional inspiratory oxygen. However, on days 4 and 5, lipid peroxidation and fractional inspiratory oxygen showed a significant correlation. Maximal amounts of expired ethane and pentane were significantly higher for patients with a poor outcome (five deaths, six cases of bronchopulmonary dysplasia) than for those with good outcome (eight infants surviving intact) (p less than 0.01). The results imply a role for free oxygen radicals in the pathogenesis of life-threatening complications in the very low birth weight infant.
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Authors | O M Pitkänen, M Hallman, S M Andersson |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 116
Issue 5
Pg. 760-4
(May 1990)
ISSN: 0022-3476 [Print] United States |
PMID | 2109791
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Free Radicals
- Pentanes
- Carbon Dioxide
- pentane
- Ethane
- Oxygen
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Topics |
- Carbon Dioxide
(analysis)
- Ethane
(analysis)
- Free Radicals
- Gestational Age
- Humans
- Infant, Low Birth Weight
(metabolism)
- Infant, Newborn
- Lipid Peroxidation
(drug effects)
- Oxygen
(analysis, blood, pharmacology)
- Oxygen Consumption
- Pentanes
(analysis)
- Prognosis
- Respiratory Distress Syndrome, Newborn
(metabolism)
- Spirometry
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