Abstract | BACKGROUND: METHODS: MGs were separated into four groups (n =15/group); H pylori (ATCC43504) was inoculated into the OPZ( omeprazole)+Hp (H pylori) and Hp groups, a PPI (OPZ) was administered to the OPZ+Hp and OPZ groups and the control group received no treatment. MGs had access to food containing omeprazole (100 mg/kg body weight/day) for 6 months, after which their stomachs were removed and cut into nine sections (six sections in the fundus and three sections in the antrum). Corpus atrophy was evaluated by the absence of parietal cells in the six sections in the fundus. First, we calculated a percentage of the area devoid of parietal cells in each haematoxylin and eosin-stained section, and then we scored the degree of atrophy by adding the percentages of the six sections. A full score was 600. RESULTS: Neutrophilic and lymphoid infiltrates were greater in the OPZ+Hp group than in the other groups. The corpus atrophy score in the OPZ+Hp group was significantly higher than that in the Hp group (p < 0.0048, Student t test). Significantly more adenocarcinomas were found in the OPZ+Hp (60%) than in the Hp (7%) group animals. CONCLUSION: Long-term PPI administration promotes development of adenocarcinoma, which is associated with the progression of atrophic corpus gastritis in MGs infected with H pylori.
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Authors | Tadashi Hagiwara, Ken-Ichi Mukaisho, Takahisa Nakayama, Hiroyuki Sugihara, Takanori Hattori |
Journal | Gut
(Gut)
Vol. 60
Issue 5
Pg. 624-30
(May 2011)
ISSN: 1468-3288 [Electronic] England |
PMID | 21097844
(Publication Type: Journal Article)
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Chemical References |
- Gastrins
- Proton Pump Inhibitors
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Topics |
- Adenocarcinoma
(chemically induced, microbiology)
- Animals
- Body Weight
- Cocarcinogenesis
- Disease Models, Animal
- Disease Progression
- Drug Administration Schedule
- Gastrins
(blood)
- Gastritis, Atrophic
(chemically induced, microbiology, pathology)
- Gerbillinae
- Helicobacter Infections
(complications)
- Helicobacter pylori
- Male
- Metaplasia
(chemically induced, microbiology)
- Proton Pump Inhibitors
(administration & dosage, toxicity)
- Stomach
(pathology)
- Stomach Neoplasms
(chemically induced, microbiology)
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