Dietary polydextrose prevents inflammatory bowel disease in trinitrobenzenesulfonic acid model of rat colitis.

Abstract	Inflammatory bowel disease (IBD) is a multifactorial intestinal disorder that involves interactions among the immune system, genetic susceptibility, and environmental factors, especially the bacterial flora. Polydextrose, a polysaccharide constituted by 90% nondigestible and nonabsorbable soluble fibers, has several physiological effects consistent with those of dietary fibers, including proliferation of colon microflora. Because sulfasalazine presents serious side effects through long-term use at high doses, the aim of the present study was to evaluate the preventative effect of polydextrose on trinitrobenzenesulfonic acid-induced intestinal inflammation and its effects on the intestinal anti-inflammatory activity of sulfasalazine. Results indicated that polydextrose and its association with sulfasalazine present an anti-inflammatory effect that reduces myeloperoxidase activity, counteracts glutathione content, and promotes reductions in lesion extension and colonic weight/length ratio.
Authors	Aline Witaicenis, Andréa C Fruet, Letícia Salem, Luiz C Di Stasi
Journal	Journal of medicinal food (J Med Food) Vol. 13 Issue 6 Pg. 1391-6 (Dec 2010) ISSN: 1557-7600 [Electronic] United States
PMID	21091252 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Gastrointestinal Agents Glucans Prebiotics Sulfasalazine Trinitrobenzenesulfonic Acid Peroxidase Alkaline Phosphatase Glutathione polydextrose
Topics	Alkaline Phosphatase (metabolism) Animals Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use) Colitis (metabolism, pathology, prevention & control) Colon (drug effects, metabolism, pathology) Drug Interactions Gastrointestinal Agents (therapeutic use) Glucans (therapeutic use) Glutathione (metabolism) Inflammatory Bowel Diseases (metabolism, pathology, prevention & control) Male Organ Size (drug effects) Oxidative Stress (drug effects) Peroxidase (metabolism) Prebiotics Random Allocation Rats Rats, Wistar Severity of Illness Index Sulfasalazine (adverse effects, therapeutic use) Trinitrobenzenesulfonic Acid (toxicity)

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