Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson's disease.

Abstract

Selegiline is a monoamine-B specific inhibitor used to treat Parkinson's disease. A Zydis sublingual preparation has more efficient absorption and less first pass amphetamine metabolites. We conducted an open label oral to Zydis switch study to evaluate tolerability of rapid switch, and relative efficacy, in 48 subjects from 5 sites. Overall patients preferred the Zydis preparation. Per clinician global impressions, fluctuations improved and the "on" UPDRS part II scores improved. Total UPDRS and measures of fatigue and sleep were unchanged. Adverse events were mild. Patients generally preferred the Zydis selegiline preparation but the modest difference is of unclear clinical significance given the open label nature of the trial.

• Authors: William G Ondo, Christine Hunter, Stuart H Isaacson, Dee E Silver, R Malcolm Stewart, James W Tetrud, Anthony Davidson
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 17 Issue 2 Pg. 117-8 (Feb 2011) ISSN: 1873-5126 [Electronic] England
• PMID: 21084213 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Selegiline

Topics

• Administration, Oral
• Administration, Sublingual
• Aged
• Chemistry, Pharmaceutical
• Drug Substitution (methods)
• Female
• Follow-Up Studies
• Humans
• Male
• Parkinson Disease (drug therapy, metabolism)
• Selegiline (administration & dosage, adverse effects)
• Treatment Outcome