Abstract | BACKGROUND: METHODS: A systematic review of the literatures on the use of palivizumab as therapy for RSV was conducted. The primary outcomes were progression from URTI to LRTI and survival rates. Secondary outcomes were adverse events due to palivizumab, serum palivizumab level, and RSV concentration in respiratory secretions. RESULTS: The search yielded 1 case report, 4 case series, and 2 randomized controlled trials (RCTs) with a total of 136 adults and children. The RCTs were not powered to look at clinical outcomes. By combining all reported clinical outcomes, 3 (12%) of 25 patients with URTI who were given palivizumab died of RSV and 5 of 88 patients with LRTI at the time of treatment died of RSV (6%). Palivizumab levels appeared to be adequate for at least 3 weeks of intravenous injection at 15 mg/kg. The therapy resulted in decreased RSV concentrations in tracheal secretions. CONCLUSION: Larger RCTs will be required before palivizumab can be recommended as therapy for RSV in any clinical setting.
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Authors | Jia Hu, Joan L Robinson |
Journal | World journal of pediatrics : WJP
(World J Pediatr)
Vol. 6
Issue 4
Pg. 296-300
(Nov 2010)
ISSN: 1867-0687 [Electronic] Switzerland |
PMID | 21080142
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antiviral Agents
- Palivizumab
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Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
- Antiviral Agents
(therapeutic use)
- Child
- Humans
- Palivizumab
- Respiratory Syncytial Virus Infections
(drug therapy)
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