The monitoring of the patients after salivary gland
tumors surgery is an important clinical issue. Still imperfect diagnostic procedures also remain a challenge for searching new sensitive and specific
biomarkers of
neoplastic processes in salivary glands. The aim of the presented study was an the assessment of the activity of HEX, with its
isoforms HEX-A and
HEX-B, GLU, GAL, MAN and FUC in salivary gland
tumor tissues in comparison to a healthy salivary gland tissues taken during autopsy. A group of 42 patients with benign and malignant salivary gland
tumors, aged 25-65 were examined. Fragments of salivary gland
tumor tissue, fragments of healthy tissue removed during autopsy, blood serum and saliva were collected from patients with salivary gland
tumors and healthy volunteers. In salivary gland
tumor tissue the activity of HEX,
HEX-A,
HEX-B, GAL, FUC was considerably higher than in comparison to healthy salivary gland tissue and ascending trend of activity of GLU, MAN was also noticed. The activity of all lysosomal
exoglycosidases in blood serum in patients with salivary gland
tumors was considerably higher in comparison to healthy volunteers blood serum. The considerably higher activity of HEX,
HEX-A, GLU, GAL, MAN, FUC and descending trend of activity of
HEX-B were noticed in saliva of patients with salivary gland
tumors in comparison to healthy volunteers. The assessment of HEX in blood serum and saliva of patients with salivary gland
tumor can be possibly used in diagnostics and monitoring of salivary glands
tumors.