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Possible lymphocyte effects on lactase expression by mouse jejunal enterocytes.

Abstract
Jejunal intraepithelial lymphocyte numbers fall and lactase activity increases during early infection with the intestinal parasite Nematospiroides dubius. Both these variables later return to values found in control mice. These results support the view that local immune reactions, suppressed by the presence of N. dubius, normally inhibit lactase expression by mouse enterocytes.
AuthorsT C Savidge, M W Smith, P J Kilshaw
JournalExperimental physiology (Exp Physiol) Vol. 75 Issue 1 Pg. 111-3 (Jan 1990) ISSN: 0958-0670 [Print] England
PMID2106904 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • CD8 Antigens
  • Galactosidases
  • beta-Galactosidase
Topics
  • Animals
  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte (immunology)
  • CD8 Antigens
  • Galactosidases (metabolism)
  • Immunoenzyme Techniques
  • Jejunum (cytology, enzymology, immunology)
  • Leukocyte Count
  • Lymphocytes (physiology)
  • Mice
  • Mice, Inbred BALB C
  • Nematode Infections (enzymology, immunology)
  • Nematospiroides dubius (immunology)
  • beta-Galactosidase (metabolism)

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