Abstract | BACKGROUND: METHODS: We determined VL setpoints in 285 HIV seroconverters using blood samples collected 6 months or more after estimated HIV seroconversion but before disease progression to CD4 ≤ 250 or WHO Stage 3 or 4. We used multivariate linear regression to estimate the effect of HC use before HIV seroconversion on VL setpoint, and multivariate Cox regression to estimate the hazards ratio of death associated with VL setpoint. RESULTS: Of 285 women, 42 (15%) reported using HC before HIV seroconversion. Mean VL setpoint was 4.49 (SD 0.79) log10 copies per milliliter among women who used HC before HIV seroconversion and 4.47 (SD 0.86) among non-HC users (P = 0.88). In multivariate analysis, HC before HIV seroconversion was not associated with VL setpoint (+0.11 log10 copies/mL; P = 0.47). Higher socioeconomic status was associated with lower VL setpoint (-0.43 log10 copies/mL; P = 0.04). VL setpoints above the median were associated with faster time to death (adjHR: 2.54, 95% confidence interval: 1.30 to 4.98, P < 0.01). CONCLUSIONS:
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Authors | Chelsea B Polis, Ronald H Gray, J B Bwanika, Godfrey Kigozi, Noah Kiwanuka, Fred Nalugoda, Joseph Kagaayi, Tom Lutalo, David Serwadda, Maria J Wawer |
Journal | Journal of acquired immune deficiency syndromes (1999)
(J Acquir Immune Defic Syndr)
Vol. 56
Issue 2
Pg. 125-30
(Feb 01 2011)
ISSN: 1944-7884 [Electronic] United States |
PMID | 21068673
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Contraceptives, Oral, Hormonal
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Topics |
- Adolescent
- Adult
- Contraceptives, Oral, Hormonal
(adverse effects)
- Drug Utilization
(statistics & numerical data)
- Female
- HIV Infections
(virology)
- HIV Seropositivity
- Humans
- Middle Aged
- Uganda
- Viral Load
- Young Adult
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