Successful zidovudine therapy for HIV-related severe thrombocytopenia. Report of a sustained remission.

Abstract

Five patients, two homosexuals and three drug abusers, with HIV-related severe thrombocytopenia, four of whom had also bleeding episodes, experienced a full remission of thrombocytopenia after 1,200 mg/day zidovudine treatment. None of the patients had acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Platelet counts began an upward trend at the end of the 3rd week and reached values higher than 140 x 10(9)/l towards the end of the 8th week of treatment. Patient's platelets remained stable after more than 4 months of active treatment. This is the first report of zidovudine-induced long-term remission of HIV-associated severe thrombocytopenia.

• Authors: J M Peña, F Arnalich, F J Barbado, A Dominguez, J Mostaza, M E Valencia, J J Vazquez
• Journal: Acta haematologica (Acta Haematol) Vol. 83 Issue 2 Pg. 86-8 ( 1990) ISSN: 0001-5792 [Print] Switzerland
• PMID: 2106201 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Zidovudine

Topics

• Acute Disease
• Adult
• HIV Infections (blood, complications, drug therapy)
• Homosexuality
• Humans
• Male
• Platelet Count (drug effects)
• Purpura, Thrombocytopenic (blood, drug therapy, etiology)
• Remission Induction
• Substance-Related Disorders (complications)
• Thrombocytopenia (blood, drug therapy, etiology)
• Zidovudine (therapeutic use)