HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Efficacy of papain-based wound cleanser in promoting wound regeneration.

Abstract
A new invention, papain-based wound cleanser is formulated by incorporating papain, a proteolytic enzyme extracted from Carica papaya into the formulation. This cleanser is invented to simplify the methods in wound management by combining wound cleansing and wound debridement using a single formulation. This study describes the preparation and preclinical study of papain-based wound cleanser in accelerating wound healing. In this study, papain-based wound cleanser was used to treat wound incision on Sprague-Dawley rats while distilled water and Betadine were used as negative and positive control. Twenty-seven clinically healthy white rats were randomly divided into three groups and treated accordingly until the 21st day post-incision. Wound reduction rates and histological analysis were obtained to asses the healing pattern. Rats treated with papain-based wound cleanser showed a progressive wound healing based on the wound reduction rates and histological analysis when compared with rats treated with distilled water and Betadine. Better collagen deposition and presence of skin organelles in rats treated with papain-based wound cleanser demonstrated its efficacy in promoting wound healing. In addition to its wound healing effect, papain-based wound cleanser is also integrated with antibacterial properties which make it a complete package for wound management. However, further studies should be carried out to ensure its safety for human usage.
AuthorsS A S H Ajlia, F A A Majid, A Suvik, M A W Effendy, H Serati Nouri
JournalPakistan journal of biological sciences : PJBS (Pak J Biol Sci) Vol. 13 Issue 12 Pg. 596-603 (Jun 15 2010) ISSN: 1028-8880 [Print] Pakistan
PMID21061910 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Papain
Topics
  • Animals
  • Debridement (methods)
  • Female
  • Humans
  • Papain (pharmacology, therapeutic use)
  • Rats
  • Rats, Sprague-Dawley
  • Regeneration (drug effects)
  • Skin (cytology, drug effects, pathology)
  • Wound Healing (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: