Abstract | OBJECTIVE:
Terlipressin has been successfully used as rescue treatment in hypotensive adults and children with septic shock, but only exceptionally in neonates. The aim of this study is to describe original clinical scenarios in which terlipressin, in newborns and infants, resolved the catecholamine-refractory hypotension. DESIGN: Retrospective study. SETTING: Neonatal intensive care unit. PATIENTS: All newborns with hypotension unresponsive to volume replacement and catecholamines, and treated with terlipressin, from January 2008 to December 2009. In this study, also an infant (11 months old) born extremely preterm was included. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: CONCLUSION: Although the number of reported infants is little, terlipressin appears to be an effective rescue treatment in different scenarios of refractory neonatal hypotension. Further controlled studies are required to confirm its efficacy and safety.
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Authors | Luca Filippi, Elena Gozzini, Marta Daniotti, Francesca Pagliai, Serena Catarzi, Patrizio Fiorini |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 12
Issue 6
Pg. e237-41
(Nov 2011)
ISSN: 1529-7535 [Print] United States |
PMID | 21057354
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Catecholamines
- Vasoconstrictor Agents
- Lypressin
- Terlipressin
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Topics |
- Catecholamines
(therapeutic use)
- Female
- Humans
- Hypotension
(diagnostic imaging, drug therapy)
- Infant
- Infant, Newborn
- Intensive Care Units, Neonatal
- Italy
- Lypressin
(administration & dosage, analogs & derivatives, therapeutic use)
- Male
- Medical Audit
- Retrospective Studies
- Shock, Septic
- Terlipressin
- Ultrasonography
- Vasoconstrictor Agents
(administration & dosage, therapeutic use)
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