[Clinical study of UFT chemotherapy in renal cancer. Kyushu University Cooperative Study Group of Renal Cancer].

Abstract

Clinical effects of UFT chemotherapy for renal cancer were evaluated by 19 collaborating hospitals. UFT (300-600 mg/day) was administered for more than 3 months. Of the 30 patients entered in this study, 21 were evaluable for the antitumor effects of the drug. Of the 21 evaluable patients, complete response (CR) was obtained in 2 patients, partial response (PR) in 1, no change (NC) in 7, progressive disease (PD) in 11, respectively. The response rate was 0% in patients with primary lesion and 21.4% in nephrectomized patients with metastatic lesion. Responses were observed in the metastases of lung, pleura and mediastinal lymph node. The main side effects in 27 patients were gastrointestinal symptoms. No significant abnormality was noted on blood laboratory data. In one patient the drug was discontinued within 3 months because of gastrointestinal symptoms. These results suggested that UFT chemotherapy for advanced renal cancer was clinically effective.

• Authors: T Ueda, J Kumazawa, A Ohmori, K Sakamoto, K Aito, I Morita, Y Ohta, T Takesue, S Hara, K Sagiyama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 17 Issue 2 Pg. 239-43 (Feb 1990) ISSN: 0385-0684 [Print] Japan
• PMID: 2105698 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Tegafur
• Uracil

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Kidney Neoplasms (drug therapy, mortality, pathology)
• Lung Neoplasms (secondary)
• Male
• Middle Aged
• Multicenter Studies as Topic
• Prognosis
• Survival Rate
• Tegafur (therapeutic use)
• Uracil (therapeutic use)