Abstract | BACKGROUND AND PURPOSE: METHODS: RNFL thickness was measured using optical coherence tomography in 17 CADASIL patients. Average values per quadrant (temporal, superior, nasal, inferior) and overall values were compared with those of normal sex- and age-matched subjects. Data of 13 patients were analyzed for correlations with MRI-based global and regional brain volumes normalized for head size. RESULTS: RNFL thickness was significantly reduced in CADASIL patients with respect to controls (p < 0.05). No significant correlations were found between RNFL thinning and brain atrophy. CONCLUSIONS: RNFL thinning suggests that retinal axonal loss occurs in CADASIL, even in the absence of subjective visual deficit.
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Authors | Alessandra Rufa, Elena Pretegiani, Paolo Frezzotti, Nicola De Stefano, Gabriele Cevenini, Maria Teresa Dotti, Antonio Federico |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 31
Issue 1
Pg. 77-82
( 2011)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 21051887
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 S. Karger AG, Basel. |
Topics |
- Adult
- Aged
- Atrophy
- Axons
(pathology)
- CADASIL
(diagnosis, pathology, physiopathology)
- Case-Control Studies
- Color Vision
- Diagnostic Techniques, Ophthalmological
- Eye Movements
- Female
- Humans
- Italy
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Predictive Value of Tests
- Retinal Neurons
(pathology)
- Tomography, Optical Coherence
- Visual Acuity
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