Long-term efficacy of inhaled N-acetylcysteine in patients with idiopathic pulmonary fibrosis.

Abstract

BACKGROUND:

Inhalation of N-acetylcysteine (NAC) has been carried out in our department since 1994 for treating interstitial pneumonia such as idiopathic pulmonary fibrosis (IPF). In this study, the clinical efficacy and safety of long-term NAC inhalation monotherapy for IPF was investigated.

METHODS:

NAC inhalation was carried out in 23 of 34 cases diagnosed as IPF by surgical lung biopsy in our department between 1994 and 2008. The treatment was continued for one year or longer in 14 cases. In these 14 cases and in 11 cases without treatment, the clinical courses, prognosis, lung function (%FVC, %DLco, and %TLC), and changes in serum markers for interstitial pneumonia (KL-6 and SP-D) were examined.

RESULTS:

There were no significant differences in survival curves between the two groups. Acute exacerbation was observed in 4 of 14 cases (28.6%) receiving NAC inhalation. Compared with the results just before the beginning of NAC inhalation, Δ%FVC and Δ%DLco in the treated cases were -4.7% and -2.9% one year later and -4.0% and -5.8% two years later, respectively. In cases without treatment, Δ%FVC and Δ%DLco were -3.5% and +5.3% one year later and +0.2% and +1.0% two years later, respectively.

CONCLUSION:

Since this study is an open case-control study in a single institute and the number of cases is not large, its use in evaluating the efficacy of NAC inhalation monotherapy is limited. In addition, the role of NAC inhalation in combination with a steroid, an immunosuppressive agent, and a new anti-fibrosis drug should also be investigated.

• Authors: Masashi Bando, Tatsuya Hosono, Naoko Mato, Takakiyo Nakaya, Hideaki Yamasawa, Shoji Ohno, Yukihiko Sugiyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 49 Issue 21 Pg. 2289-96 ( 2010) ISSN: 1349-7235 [Electronic] Japan
• PMID: 21048362 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetylcysteine

Topics

• Acetylcysteine (administration & dosage)
• Administration, Inhalation
• Aged
• Case-Control Studies
• Female
• Humans
• Idiopathic Pulmonary Fibrosis (diagnosis, drug therapy, mortality)
• Male
• Middle Aged
• Respiratory Function Tests (trends)
• Retrospective Studies
• Time Factors
• Treatment Outcome