Abstract | PURPOSE: The use of hypertonic saline injection in trauma patients is discussed. SUMMARY: Patients with hemorrhage, burns, and traumatic brain injury (TBI) may develop hypovolemic shock and require resuscitation. Compared with conventional isotonic crystalloids, hypertonic saline has several advantages, including hemodynamic, immune-modulating, and antiinflammatory effects, for use in trauma patients for resuscitation. In addition, hypertonic saline is also used in patients with TBI to reduce intracranial pressure (ICP). Overall, studies have not shown a difference in mortality or other clinically important outcomes with the use of hypertonic saline for resuscitation in trauma patients; however, most of these studies were not adequately powered to show significant differences. A recent Cochrane review concluded that there is no evidence that hypertonic crystalloids are better than isotonic or near-isotonic crystalloids for fluid resuscitation in trauma patients. Two recent trials that were adequately powered to investigate a mortality endpoint were halted for futility. A few small randomized controlled studies found that hypertonic saline was more effective than mannitol as a hyperosmolar agent for ICP reduction. Recent guidelines from the American Burn Association have suggested that hypertonic saline may be used for burn shock resuscitation by experienced providers with close monitoring to avoid excessive hypernatremia. One of the main concerns with the use of hypertonic saline is its potential to cause central pontine myelinolysis due to a rapid increase in serum sodium levels. CONCLUSION:
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Authors | Asad E Patanwala, Albert Amini, Brian L Erstad |
Journal | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
(Am J Health Syst Pharm)
Vol. 67
Issue 22
Pg. 1920-8
(Nov 15 2010)
ISSN: 1535-2900 [Electronic] England |
PMID | 21048208
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Crystalloid Solutions
- Isotonic Solutions
- Saline Solution, Hypertonic
- Mannitol
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Topics |
- Animals
- Brain Injuries
(complications, physiopathology, therapy)
- Burns
(complications)
- Crystalloid Solutions
- Hemorrhage
(complications, therapy)
- Humans
- Isotonic Solutions
(therapeutic use)
- Mannitol
(therapeutic use)
- Practice Guidelines as Topic
- Saline Solution, Hypertonic
(adverse effects, therapeutic use)
- Shock
(etiology, therapy)
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