Abstract | BACKGROUND:
Fluconazole prophylaxis is effective in preventing invasive candidiasis in extremely low- birthweight (ELBW) infants. The authors previously reported an increased incidence of cholestasis with fluconazole prophylaxis in ELBW infants, which led to fluconazole prophylaxis being changed to a less frequent dosing (LFD) schedule of twice a week at their institution. The purpose of the present study was therefore to evaluate the effectiveness and safety of LFD fluconazole prophylaxis in preventing invasive candidiasis in ELBW infants. METHODS: ELBW infants who received the LFD regimen of fluconazole (twice a week for up to 6 weeks) were compared with infants who received the frequent dosing (FD) schedule (every 72 h for first 2 weeks, every 48 h for next 2 weeks and every 24 h for the final 2 weeks). The two groups were compared for baseline demographics, risk factors for candidiasis, the rate of invasive fungal infection and the incidence and severity of cholestasis. RESULTS: There was no significant difference in the incidence of invasive candidiasis in infants who received the LFD (2/104, 2%) compared to FD (0/140, 0%; P= 0.4) fluconazole prophylaxis. The severity of cholestasis was lower and a trend towards decreased incidence of cholestasis was observed on the LFD schedule. CONCLUSION:
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Authors | Vishwanath Bhat, Milliecor Fojas, Judy G Saslow, Sahil Shah, Sulaiman Sannoh, Barbara Amendolia, Kee Pyon, Nicole Kemble, Gary Stahl, Zubair H Aghai |
Journal | Pediatrics international : official journal of the Japan Pediatric Society
(Pediatr Int)
Vol. 53
Issue 4
Pg. 475-9
(Aug 2011)
ISSN: 1442-200X [Electronic] Australia |
PMID | 21040197
(Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
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Copyright | © 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society. |
Chemical References |
- Antifungal Agents
- Fluconazole
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Topics |
- Antifungal Agents
(administration & dosage, adverse effects, therapeutic use)
- Candidiasis, Invasive
(epidemiology, prevention & control)
- Cholestasis
(chemically induced, epidemiology)
- Drug Administration Schedule
- Female
- Fluconazole
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Incidence
- Infant, Extremely Low Birth Weight
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
(prevention & control)
- Linear Models
- Male
- Retrospective Studies
- Risk Factors
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