Studies on the comparative efficacy of mebendazole, flubendazole and niclosamide against human tapeworm infections.

Abstract

The efficacy of Mebendazole and Niclosamide was studied in two groups of 24 and 38 cases, respectively of patients suffering from taeniasis. Mebendazole with dose schedule of 200 and 300 mg twice daily for 3 consecutive days showed a cure rate of 71.42% and 92.30%, whereas Niclosamide at the dose rate of 200mg per patient was 94.76% effective. Flubendazole showed a cure rate of 66.66% only. Mebendazole and Niclosamide possess high taeniacidal activity, ability to reduce the clinical symptoms of taeniasis without any side effects. Niclosamide with high activity and excellent tolerance, is a drug of choice for the treatment of taeniasis in single dose treatment while for hymenolepsiasis it needs extended course.

• Authors: T K Varma, T N Shinghal, M Saxena, S S Ahluwalia
• Journal: Indian journal of public health (Indian J Public Health) 1990 Jul-Sep Vol. 34 Issue 3 Pg. 163-8 ISSN: 0019-557X [Print] India
• PMID: 2103926 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antinematodal Agents
• Mebendazole
• Niclosamide
• flubendazole

Topics

• Antinematodal Agents (therapeutic use)
• Cestode Infections (drug therapy)
• Drug Administration Schedule
• Drug Evaluation
• Humans
• Mebendazole (administration & dosage, analogs & derivatives, therapeutic use)
• Niclosamide (administration & dosage, therapeutic use)
• Taeniasis (drug therapy)