Abstract | BACKGROUND: METHODS: The expression of CK19, galectin-3, HBME-1 and MIB-1 was detected by immunohistochemical staining in 12 cases of hyalinizing trabecular tumor and 20 cases of thyroid papillary carcinoma. RESULTS: Two of the 12 HTT samples were positive or focally positive for CK19. Four of the 12 samples of HTT presented positive to galectin-3; 3 were stained strongly and the other one was focally positive. None of the 12 samples of HTT was positive for HBME-1. Five in 12 HTT samples were stained in nucleus for MIB-1. Almost all the 20 cases of thyroid papillary carcinoma were intensely stained for CK19, galectin-3 and HBME-1. Fifteen in 20 cases of thyroid papillary carcinoma showed nuclear staining for MIB-1. CONCLUSIONS: HTT is an independent thyroid neoplasm, not a variant of TPC. This study could help in the differential diagnosis of HTT from TPC. CK19, galectin-3 and HBME-1 are adequate to identify HTT and TPC, but MIB-1 does not play an important role in discrimination between HTT and TPC.
|
Authors | Hong Zhu, Ji-ping Qi, Ying-wei Wang, Yue-jia Song, Zhi-yi Zhang |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 123
Issue 20
Pg. 2832-5
(Oct 2010)
ISSN: 2542-5641 [Electronic] China |
PMID | 21034592
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Galectin 3
- HBME-1 antigen
- Keratin-19
- MIB1 ligase, human
- Ubiquitin-Protein Ligases
|
Topics |
- Adolescent
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- Carcinoma, Papillary
(chemistry, diagnosis)
- Child
- Diagnosis, Differential
- Female
- Galectin 3
(analysis)
- Humans
- Immunohistochemistry
- Keratin-19
(analysis)
- Male
- Middle Aged
- Thyroid Neoplasms
(chemistry, diagnosis)
- Ubiquitin-Protein Ligases
(analysis)
|