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Hepatic toxicity of vitamin A and synthetic retinoids.

Abstract
Vitamin A and synthetic retinoids have recently been used increasingly in a variety of health related concerns. Hepatic toxicity is an uncommon but serious side-effect of several Vitamin A derivatives which may lead to cirrhosis. This review will focus on the clinical and pathologic findings of hepatic involvement in chronic hypervitaminosis A and on the evidence concerning the potential hepatotoxicity of currently available synthetic retinoids.
AuthorsM B Fallon, J L Boyer
JournalJournal of gastroenterology and hepatology (J Gastroenterol Hepatol) 1990 May-Jun Vol. 5 Issue 3 Pg. 334-42 ISSN: 0815-9319 [Print] Australia
PMID2103414 (Publication Type: Journal Article, Review)
Chemical References
  • Etretinate
  • Isotretinoin
Topics
  • Chemical and Drug Induced Liver Injury (etiology, pathology)
  • Etretinate (pharmacokinetics, toxicity)
  • Female
  • Humans
  • Hypervitaminosis A (etiology, pathology)
  • Isotretinoin (pharmacokinetics, toxicity)
  • Liver (drug effects)
  • Male

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