Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial.

Abstract

PURPOSE:

We aimed to compare therapeutic effects of intramuscular (IM) nandrolone decanoate and IM testosterone enanthate in male HIV patients with AIDS wasting syndrome (AWS) with placebo control.

METHODS:

In this randomized, double-blind, placebo-controlled, 12-week trial, 104 patients with AWS who satisfied our inclusion criteria were randomly allotted in a 2:2:1 ratio to the 3 intervention groups: nandrolone, testosterone, and placebo. We administered 150 mg nandrolone and 250 mg testosterone (both IM, biweekly). The primary outcome measure was a comparison of absolute change in weight at 12 weeks between the nandrolone decanoate, testosterone, and placebo groups.

RESULTS:

Intent-to-treat analysis was done. The nandrolone group recorded maximum mean increase in weight (3.20 kg; post hoc P < .01 compared to placebo). Body mass index (BMI) of subjects in the nandrolone group had a significantly greater increase (mean = 1.28) compared to both testosterone (post hoc P < .05) and placebo (post hoc P < .01). Waist circumference and triceps skinfold thickness of patients on nandrolone showed similar results. Nandrolone also ensured a better quality of life. Patients with low testosterone level (<3 ng/mL) benefited immensely from nandrolone therapy, which increased their weight and BMI significantly compared to placebo (P < .05).

CONCLUSION:

Our trial demonstrates the superior therapeutic effects of nandrolone in male AWS patients, including the androgen deficient.

• Authors: Partha Sardar, Ayan Jha, Deeptarka Roy, Uddalak Majumdar, Pradipta Guha, Sabyasachi Roy, Ramtanu Banerjee, Amit Kumar Banerjee, Dipanjan Bandyopadhyay
• Journal: HIV clinical trials (HIV Clin Trials) 2010 Jul-Aug Vol. 11 Issue 4 Pg. 220-9 ISSN: 1528-4336 [Print] England
• PMID: 20974577 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Testosterone
• Nandrolone
• testosterone enanthate
• Luteinizing Hormone
• Follicle Stimulating Hormone
• Nandrolone Decanoate

Topics

• Adult
• Body Composition (physiology)
• Body Mass Index
• Double-Blind Method
• Follicle Stimulating Hormone (blood)
• HIV (immunology)
• HIV Infections (blood, drug therapy, immunology)
• HIV Wasting Syndrome (blood, drug therapy, immunology, virology)
• Humans
• Injections, Intramuscular
• Luteinizing Hormone (blood)
• Male
• Nandrolone (administration & dosage, analogs & derivatives)
• Nandrolone Decanoate
• Quality of Life
• Skinfold Thickness
• Testosterone (administration & dosage, analogs & derivatives)
• Waist Circumference (physiology)
• Weight Gain (drug effects, physiology)