Coexistence of chronic myeloid leukemia and pulmonary plasmacytoma mimicking primary lung cancer.

Abstract

A 61-year-old man was diagnosed with the simultaneous occurrence of chronic myeloid leukemia (CML) and infiltrative intrathoracic plasmacytoma, radiologically mimicking bronchogenic carcinoma. Following the administration of imatinib mesylate (IM; 400 mg/day), both hematologic and partial cytogenetic remission of CML were achieved. However, the pulmonary plasmacytoma was persistently aggravated. High-dose dexamethasone was added to the IM therapy because the patient refused radiotherapy to control the aggravated pulmonary plasmacytoma. Finally, he died due to pneumonia and multi-organ failure during concurrent administration of IM and high-dose dexamethasone.

• Authors: Hee Jin Kim, Moon Jin Kim, Min Jeong Lee, Jong-Hwa Ahn, Ho-Su Kim, In-Suk Kim, Jong Sil Lee, Gyeong-Won Lee
• Journal: International journal of hematology (Int J Hematol) Vol. 92 Issue 4 Pg. 651-4 (Nov 2010) ISSN: 1865-3774 [Electronic] Japan
• PMID: 20967517 (Publication Type: Case Reports, Journal Article)

Topics

• Carcinoma, Bronchogenic (diagnosis)
• Diagnosis, Differential
• Fatal Outcome
• Humans
• Leukemia, Myeloid, Chronic-Phase (diagnosis, drug therapy)
• Lung Neoplasms (diagnosis)
• Male
• Middle Aged
• Neoplasms, Multiple Primary (diagnosis, drug therapy)
• Plasmacytoma (diagnosis, drug therapy)
• Thoracic Neoplasms (diagnosis, drug therapy)