Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population.

Abstract

The development of allergic rhinitis is considered to be determined by the interaction between genetic and environmental factors. Surfactant protein A (SP-A), a member of the collectin family of proteins, plays an important role in immune regulation. The purpose of this study was to investigate the association between SP-A polymorphisms and allergic rhinitis. We conducted a case-control association study on a Chinese Han population, comprising 216 adult individuals with AR and 84 healthy controls. A total of 9 single-nucleotide polymorphisms (SNPs) mapped to the SP-A were genotyped using PCR-based molecular identification methods. The frequency of A allele at amino acid 223 in the patient group was significantly higher than that in the control group after correcting for multiple testing (P = 0.006). The 1A(2) allele haplotype in SFTPA2 was associated with decreased risk for allergic rhinitis, after applying Bonferroni corrections (P = 0.003). However, genetic variants of the SFTPA1 genes were not found to be associated with AR. In addition, no significant associations were established between any of the 9 SFTPA gene polymorphisms and the skin-prick test responses (P > 0.05). Further, no association was established between the 9 SNP loci and the levels of total serum immunoglobulin E (IgE) (P > 0.05). These results indicate that the gene polymorphism at the residue 223 in the carbohydrate recognition domain of SFTPA2 may be a genetic marker for the development of AR in the adult Chinese Han population.

• Authors: Yuqin Deng, Shiming Chen, Jinhui Chen, Zezhang Tao, Yonggang Kong, Yu Xu, Bokui Xiao, Qing He
• Journal: Molecular biology reports (Mol Biol Rep) Vol. 38 Issue 3 Pg. 1475-82 (Mar 2011) ISSN: 1573-4978 [Electronic] Netherlands
• PMID: 20963503 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pulmonary Surfactant-Associated Protein A
• SFTPA1 protein, human
• SFTPA2 protein, human

Topics

• Adult
• Aged
• Asian People (genetics)
• Case-Control Studies
• Ethnicity (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Haplotypes (genetics)
• Humans
• Linkage Disequilibrium (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide
• Pulmonary Surfactant-Associated Protein A (genetics)
• Rhinitis, Allergic, Perennial (genetics)
• Young Adult