Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro.

In the past 5 years, the incidence of canine skin infections caused by resistant strains of Staphylococcus (pseud)intermedius has increased. Many older antibiotics are used to treat these infections because the sensitivity can be demonstrated in vitro. Additionally, many of these older drugs are efficacious and unlikely to induce multidrug resistance. More than a decade ago, the antibiotic tylosin tartrate was reported to be efficacious in vitro and in vivo against Staphylococcus intermedius. The purpose of this study was to determine whether S. (pseud)intermedius isolated from untreated pyoderma cases at veterinary referral centers across the United States are sensitive in vitro to this antibiotic. Minimum inhibitory concentrations for tylosin tartrate and other commonly used antibiotics were determined for 103 isolates. Most (82.61%) of the isolates not exposed to antibiotics in the 3 months before submission were sensitive to tylosin tartrate. These findings suggest that tylosin tartrate warrants further study as a first-line option for the treatment of dogs initially presenting with pyoderma.
AuthorsBrian A Scott, Joel E Mortensen, Tricia M McKeever, Dawn B Logas, Patrick J McKeever
JournalVeterinary therapeutics : research in applied veterinary medicine (Vet Ther) Vol. 11 Issue 3 Pg. E1-7 ( 2010) ISSN: 1528-3593 [Print] United States
PMID20960412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Tylosin
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Dog Diseases (microbiology)
  • Dogs
  • Staphylococcal Skin Infections (microbiology, veterinary)
  • Staphylococcus intermedius (drug effects)
  • Tylosin (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: