Markers of bone remodeling in neoplastic and bone-related lesions.

Abstract

OBJECTIVE:

The aim of this study was to investigate the expression of bone resorption (RANK/RANKL), bone resorption inhibitor (osteoprotererin [OPG]), and bone formation marker (osteocalcin [OC]) in neoplastic and bone-related lesions (BRL).

STUDY DESIGN:

Using immunohistochemistry, their expression was evaluated in ossifying fibroma (OF), fibrous dysplasia (FD), simple bone cysts (SBC), central giant cell lesions (CGCL), and osteosarcoma (OS).

RESULTS:

Quantitative analyses of the expression of bone markers between all lesions, considering fibroblast-like cells and bone matrix, showed that RANK-RANKL presented higher expression in OF and CGCL, whereas OPG and OC presented higher expression in FD and SBC. There was higher expression of all proteins investigated when OS was the BRL. Moreover, the RANKL expression was greater than OPG in this neoplasm.

CONCLUSION:

Our data indicate that the bone resorption markers are more highly expressed in OF, CGCL, and OS than in FD and SBC, indicating a significant association between these proteins and the clinical behavior of these lesions.

• Authors: Larissa Santana Arantes Elias, Rafael Ferreira Costa, Marco Aurélio Carvalho, Aline Carvalho Batista, Tarcília Aparecida Silva, Cláudio Rodrigues Leles, Elismauro Francisco Mendonça
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 110 Issue 5 Pg. 624-31 (Nov 2010) ISSN: 1528-395X [Electronic] United States
• PMID: 20955951 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Mosby, Inc. All rights reserved.

Chemical References

• Biomarkers
• Biomarkers, Tumor
• Osteoprotegerin
• RANK Ligand
• Receptor Activator of Nuclear Factor-kappa B
• TNFRSF11A protein, human
• TNFRSF11B protein, human
• Osteocalcin

Topics

• Adolescent
• Adult
• Biomarkers (analysis)
• Biomarkers, Tumor (analysis)
• Bone Matrix (pathology)
• Bone Remodeling (physiology)
• Bone Resorption (physiopathology)
• Child
• Female
• Fibroblasts (pathology)
• Fibroma, Ossifying (pathology)
• Fibrous Dysplasia of Bone (pathology)
• Giant Cells (pathology)
• Granuloma, Giant Cell (pathology)
• Humans
• Jaw Cysts (pathology)
• Jaw Diseases (pathology)
• Jaw Neoplasms (pathology)
• Male
• Middle Aged
• Osteoblasts (pathology)
• Osteocalcin (analysis)
• Osteoclasts (pathology)
• Osteogenesis (physiology)
• Osteoprotegerin (analysis)
• Osteosarcoma (pathology)
• RANK Ligand (analysis)
• Receptor Activator of Nuclear Factor-kappa B (analysis)
• Stromal Cells (pathology)
• Young Adult