Abstract | BACKGROUND: METHODS: We performed a randomized, double-blinded, prospective crossover study in 17 patients admitted to our trauma intensive care unit (ICU) with evidence of impaired renal function. Patients were randomized to a 24-h intravenous infusion of low-dose fenoldopam or placebo. When the infusion of fenoldopam or placebo was completed, patients underwent a 24-h "washout" period in which no study intervention was performed. This sequence was repeated in each patient with the opposite agent, so each patient served as his own control. Four-hour creatinine collections were taken during the last 4 h of each infusion and washout periods to determine creatinine clearance changes during and after the administration of the study drug. RESULTS: The creatinine clearance was higher with fenoldopam infusion than with placebo infusion (P = 0.045). The FENa was not significantly different. CONCLUSIONS:
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Authors | Miguel Cobas, Gian Paparcuri, Maria De La Pena, Gaston Cudemus, Erik Barquist, Albert Varon |
Journal | Cardiovascular therapeutics
(Cardiovasc Ther)
Vol. 29
Issue 4
Pg. 280-4
(Aug 2011)
ISSN: 1755-5922 [Electronic] England |
PMID | 20955210
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 Blackwell Publishing Ltd. |
Chemical References |
- Dopamine Agonists
- Fenoldopam
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Topics |
- Acute Kidney Injury
(drug therapy, physiopathology)
- Adult
- Aged
- Critical Illness
- Cross-Over Studies
- Dopamine Agonists
(therapeutic use)
- Double-Blind Method
- Fenoldopam
(therapeutic use)
- Humans
- Middle Aged
- Prospective Studies
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