Porcine dermal collagen matrix injection may enhance flap repair surgery for complex anal fistula.

Abstract

INTRODUCTION:

The use of biomaterials to treat anal fistula has drawn great interest. More recently, a porcine dermal matrix injection has been proposed as infill biomaterial to treat fistulas.

METHODS:

We propose a novel approach consisting in non-cutting seton positioning followed by flap repair associated with dermal matrix injection into the fistula tracts after several weeks.

RESULTS:

We report our experience with this two-staged procedure on 11 consecutive patients with recurrent high trans-sphincteric fistulas with a minimum follow-up of 6 months.

CONCLUSIONS:

In our experience, this two-stage approach seems to be safe and effective.

• Authors: Pierpaolo Sileri, Luana Franceschilli, Giovanna Del Vecchio Blanco, Vito M Stolfi, Giulio P Angelucci, Achille L Gaspari
• Journal: International journal of colorectal disease (Int J Colorectal Dis) Vol. 26 Issue 3 Pg. 345-9 (Mar 2011) ISSN: 1432-1262 [Electronic] Germany
• PMID: 20953873 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Collagen

Topics

• Adolescent
• Adult
• Aged
• Animals
• Collagen (administration & dosage, pharmacology, therapeutic use)
• Dermis (metabolism)
• Extracellular Matrix (metabolism)
• Female
• Follow-Up Studies
• Humans
• Injections
• Male
• Middle Aged
• Rectal Fistula (surgery)
• Surgical Flaps
• Sus scrofa
• Wound Healing (drug effects)
• Young Adult