[The chemiluminescence of the polymorphonuclear leukocytes in food poisoning].

Abstract

Luminol- and lucigenin-dependent chemiluminescence (CL) induced by zymosan, opsonized autoserum was used to study the oxygen-dependent bactericidal system of polymorphonuclear leukocytes (PNL) in patients with food toxico-infections, at different disease periods. Different modifications of CL were established to have analogous dynamics on days 1 and 2 of the disease and differences as to the period of convalescence. A correlation was revealed between the amplitude of CL and the intensity of the intoxication syndrome. The conclusion is made about the role played by granulocytes in the disease pathogenesis. The authors review potential mechanisms of participation of PNL free radicals in the pathophysiological shifts responsible for the development, course and outcome of food toxico-infections.

• Authors: P Iu Popov, I M Roslyĭ, V A Malov, S G Pak
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 62 Issue 11 Pg. 28-30 ( 1990) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Khemiliuminestsentsiia polimorfnoiadernykh leĭkotsitov pri pishchevykh toksikoinfektsiiakh.
• PMID: 2094985 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Acridines
• Opsonin Proteins
• 10,10'-dimethyl-9,9'-biacridinium
• Luminol

Topics

• Acridines
• Adolescent
• Adult
• Humans
• Luminescent Measurements
• Luminol
• Middle Aged
• Neutrophils (drug effects, metabolism)
• Opsonin Proteins (drug effects, physiology)
• Phagocytosis (drug effects, physiology)
• Salmonella Food Poisoning (blood)
• Time Factors