Abstract | BACKGROUND: METHODS: Balb/C mice were infected with Echinococcus granulosus protoscoleces. One day after infection, the animals were allocated into 3 different experimental groups: unmedicated control and treated at the time point of infection with flubendazole either prepared as a solution or suspension given twice a day during 15 days. Six months after infection, the animals were sacrificed to collect and weight parasitic cysts. Cyst samples recovered from infected mice of each experimental group were prepared for both scanning and transmission electron microscopy. RESULTS: Both flubendazole formulations induced a significant reduction in cyst weight compared to the cysts recovered from the unmedicated control animals. Both formulations showed similar flubendazole-induced ultrastructural morphological changes. CONCLUSION:
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Authors | Laura Ceballos, Celina Elissondo, Sergio Sánchez Bruni, Alejandra Confalonieri, Guillermo Denegri, Luis Alvarez, Carlos Lanusse |
Journal | Chemotherapy
(Chemotherapy)
Vol. 56
Issue 5
Pg. 386-92
( 2010)
ISSN: 1421-9794 [Electronic] Switzerland |
PMID | 20948209
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 S. Karger AG, Basel. |
Chemical References |
- Antinematodal Agents
- beta-Cyclodextrins
- 2-Hydroxypropyl-beta-cyclodextrin
- Mebendazole
- Carboxymethylcellulose Sodium
- flubendazole
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Topics |
- 2-Hydroxypropyl-beta-cyclodextrin
- Animals
- Antinematodal Agents
(therapeutic use)
- Carboxymethylcellulose Sodium
(chemistry)
- Chemistry, Pharmaceutical
- Disease Models, Animal
- Echinococcosis
(pathology, prevention & control)
- Mebendazole
(analogs & derivatives, therapeutic use)
- Mice
- Mice, Inbred BALB C
- Microscopy, Electron, Scanning
- Microscopy, Electron, Transmission
- beta-Cyclodextrins
(chemistry)
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