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Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs.

Abstract
We describe herein for the first time our medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and boron tracedrugs as newly emerging drug classes. A new area of antineoplastic drugs and treatments has recently focused on neoplastic cells of the tumor environment/microenvironment involving accessory cells. This tumor hypoxic environment is now considered as a major factor that influences not only the response to antineoplastic therapies but also the potential for malignant progression and metastasis. We review our medicinal electronomics bricolage design of hypoxia-targeting drugs, antiangiogenic hypoxic cell radiosensitizers, sugar-hybrid hypoxic cell radiosensitizers, and hypoxia-targeting 10B delivery agents, in which we design drug candidates based on their electronic structures obtained by molecular orbital calculations, not based solely on pharmacophore development. These drugs include an antiangiogenic hypoxic cell radiosensitizer TX-2036, a sugar-hybrid hypoxic cell radiosensitizer TX-2244, new hypoxia-targeting indoleamine 2,3-dioxygenase (IDO) inhibitors, and a hypoxia-targeting BNCT agent, BSH (sodium borocaptate-10B)-hypoxic cytotoxin tirapazamine (TPZ) hybrid drug TX-2100. We then discuss the concept of boron tracedrugs as a new drug class having broad potential in many areas.
AuthorsHitoshi Hori, Yoshihiro Uto, Eiji Nakata
JournalAnticancer research (Anticancer Res) Vol. 30 Issue 9 Pg. 3233-42 (Sep 2010) ISSN: 1791-7530 [Electronic] Greece
PMID20944092 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Boron Compounds
  • Radiation-Sensitizing Agents
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, chemistry)
  • Boron Compounds (chemical synthesis, chemistry)
  • Cell Hypoxia (drug effects)
  • Drug Design
  • Electrons
  • Humans
  • Neoplasms (drug therapy)
  • Radiation-Sensitizing Agents (chemical synthesis, chemistry)

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