Abstract | OBJECTIVE: METHOD: Study of TSA on rat cerebral ischemia in vivo: Male SD rats were divided into four groups ( sham-operated, ischemic and treated group (lower dose and higher dose). Chronic cerebral ischemmia after permanent bilateral carotid artery ligation was introduced as an in vivo ischemic model. After ischemia impairment, TSA (2, 4 mg x kg(-1) x d(-1)) was administrated by ip for 30 days in treated group. We used Morris water maze to investigate the learning and memory. Levels of malondialdehyde (MDA), activity of superoxide dismetase (SOD) and glutathione peroxidase (GPX) in brain tissue were detected by spectrophotometer. High-performance liquid chromatography (HPLC) with fluorescence detection was applied to measure the contents of glutamate and gamma-aminobutyric acid ( GABA) in cortex and hippocampus. RESULTS: CONCLUSION:
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Authors | Zhi He, Zhihong Pan, Wenhong Lu |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 35
Issue 14
Pg. 1883-6
(Jul 2010)
ISSN: 1001-5302 [Print] China |
PMID | 20939291
(Publication Type: Journal Article)
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Chemical References |
- Abietanes
- Drugs, Chinese Herbal
- Neuroprotective Agents
- Phenanthrenes
- tanshinone
- Malondialdehyde
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Topics |
- Abietanes
- Animals
- Dementia, Vascular
(drug therapy, metabolism, physiopathology)
- Disease Models, Animal
- Drugs, Chinese Herbal
(administration & dosage)
- Humans
- Male
- Malondialdehyde
(metabolism)
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Neuroprotective Agents
(administration & dosage)
- Phenanthrenes
(administration & dosage)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
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