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APF and dentifrice effect on root dentin demineralization and biofilm.

Abstract
Because dentin is more caries-susceptible than enamel, its demineralization may be more influenced by additional fluoride (F). We hypothesized that a combination of professional F, applied as acidulated phosphate F (APF), and use of 1100-ppm-F dentifrice would provide additional protection for dentin compared with 1100-ppm-F alone. Twelve adult volunteers wore palatal appliances containing root dentin slabs, which were subjected, during 4 experimental phases of 7 days each, to biofilm accumulation and sucrose exposure 8x/day. The volunteers were randomly assigned to the following treatments: placebo dentifrice (PD), 1100-ppm-F dentifrice (FD), APF + PD, and APF+FD. APF gel (1.23% F) was applied to the slabs once at the beginning of the experimental phase, and the dentifrices were used 3x/day. APF and FD increased F concentration in biofilm fluid and reduced root dentin demineralization, presenting an additive effect. Analysis of the data suggests that the combination of APF gel application and daily regular use of 1100-ppm-F dentifrice may provide additional protection against root caries compared with the dentifrice alone.
AuthorsG C Vale, C P M Tabchoury, A A Del Bel Cury, L M A Tenuta, J M ten Cate, J A Cury
JournalJournal of dental research (J Dent Res) Vol. 90 Issue 1 Pg. 77-81 (Jan 2011) ISSN: 1544-0591 [Electronic] United States
PMID20929723 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Apatites
  • Cariogenic Agents
  • Cariostatic Agents
  • Dentifrices
  • Drug Combinations
  • Gels
  • Placebos
  • Acidulated Phosphate Fluoride
  • Sucrose
  • fluorapatite
  • Calcium Fluoride
  • Fluorides
Topics
  • Acidulated Phosphate Fluoride (administration & dosage, therapeutic use)
  • Adult
  • Apatites (analysis)
  • Biofilms (drug effects)
  • Calcium Fluoride (analysis)
  • Cariogenic Agents (adverse effects)
  • Cariostatic Agents (administration & dosage, therapeutic use)
  • Cross-Over Studies
  • Dental Plaque (microbiology)
  • Dentifrices (administration & dosage, therapeutic use)
  • Dentin (drug effects, microbiology)
  • Double-Blind Method
  • Drug Combinations
  • Fluorides (administration & dosage, therapeutic use)
  • Gels
  • Hardness
  • Humans
  • Microradiography
  • Placebos
  • Sucrose (adverse effects)
  • Time Factors
  • Tooth Demineralization (prevention & control)
  • Tooth Root (drug effects, microbiology)
  • Young Adult

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