Abstract | BACKGROUND: OBJECTIVE: To evaluate the trends of ciprofloxacin resistance pattern in commonly isolated gram-positive bacteria over time in a Saudi Arabian teaching hospital. METHODS: A retrospective analysis was carried out for ciprofloxacin susceptibility patterns of 5534 isolates of gram-positive bacteria isolated from clinical specimens submitted to microbiology laboratories at King Fahd Hospital of the University (KFHU), Al-Khobar, Saudi Arabia during the period from January 2002 to August 2005. RESULTS: Increase in ciprofloxacin resistance rates with some fluctuations, among these isolates, were observed. For Staphylococcus aureus, it varied from 4.62, 1.83, 7.01 and 3.98%, methicillin resistant Staphylococcus aureus (MRSA) 97.92, 97.75, 87.01 and 88.26%, Streptococcus pyogenes 5.35, 4.47, 14.44 and 3.53% during the years 2002, 2003, 2004 and 2005 respectively. Cirprofloxacin resistance during the years 2002, 2004 and 2005 for other isolates was as follows: Streptococcus pneumoniae, 30.23, 23.02 and 26.47%; enterococcus group D, 43.05, 20.68 and 57.03% and non-enterococcus group D, 62.96, 76.92 and 87.50% respectively. CONCLUSION:
Ciprofloxacin resistance in gram-positive bacterial clinical isolates particularly Staphylococcus aureus, methicillin resistant Staphylococcus aureus (MRSA) enterococcus group D, and non-enterococcus group D, has greatly increased and ciprofloxacin no more remains the drug of choice for these infections.
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Authors | Naeem Akhtar, Alhusain Alzahrani, Obeid El-Treify Obeid, Dennis Dassal |
Journal | Journal of Ayub Medical College, Abbottabad : JAMC
(J Ayub Med Coll Abbottabad)
2009 Jul-Sep
Vol. 21
Issue 3
Pg. 54-6
ISSN: 1025-9589 [Print] Pakistan |
PMID | 20929013
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Ciprofloxacin
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Topics |
- Anti-Infective Agents
(pharmacology)
- Ciprofloxacin
(pharmacology)
- Drug Resistance, Microbial
- Gram-Positive Bacteria
(drug effects, isolation & purification)
- Hospitals, Teaching
- Humans
- In Vitro Techniques
- Microbial Sensitivity Tests
- Retrospective Studies
- Saudi Arabia
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