[Fetal hemolytic disease in a patient immunized by six antibodies: diagnosis and treatment].

Abstract

A case of severe haemolytic disease of the fetus due to six rare alloantibodies is described. In a pregnant women at 23 weeks gestation after the finding of a positive indirect Coombs test maternal antibodies have been precisely identified and titrated: anti-I: 1/23, anti-c: 1/64, anti-S: 1/16, anti-Fya: 1/128, anti-M: 1/64, anti-Jka: 1/32000. Fetal blood group, free and red blood cell adherent antibodies have been investigated on fetal blood samples obtained by means of cord centesis. A compatible donor has been found. Severe fetal anemia has been corrected by ultrasound guided intrauterine transfusions (one abdominal and two intravascular transfusions) with positive outcome of the pregnancy.

• Authors: V Tantalo, E Rossi, G A Gianotti, R Morotti, G Zuliani, M Buscaglia, M Galligani
• Journal: Annali di ostetricia, ginecologia, medicina perinatale (Ann Ostet Ginecol Med Perinat) 1990 Sep-Oct Vol. 111 Issue 5 Pg. 321-5 ISSN: 0300-0087 [Print] Italy
• Vernacular Title: Malattia emolitica fetale in una paziente immunizzata da sei anticorpi: diagnosi e trattamento.
• PMID: 2092607 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Isoantibodies

Topics

• Adult
• Blood Transfusion, Intrauterine
• Erythroblastosis, Fetal (immunology, therapy)
• Female
• Humans
• Infant, Newborn
• Isoantibodies (analysis)
• Pregnancy
• Ultrasonography, Prenatal