Abstract | BACKGROUND: In the recent years, surgical resection with pre- and/or postoperative chemotherapy has markedly improved the survival rate of hepatoblastoma patients. We herein report the results of patients treated with the current protocol of the Japanese Study Group for Pediatric Liver Tumor, JPLT-2. METHODS: RESULTS: The 5-year overall survival rate (OS) in non-metastatic cases was 100% for PRETEXT I, 87.1% for PRETEXT II, 89.7% for PRETEXT III, and 78.3% for PRETEXT IV. The 5-year OS in metastatic cases was 43.9%. The outcome in non-metastatic PRETEXT IV cases was markedly improved, while the results of metastatic tumors remained poor. CONCLUSIONS: JPLT-2 protocol achieved satisfactory survival among children with non-metastatic hepatoblastoma. New approaches are needed for patients with metastatic diseases.
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Authors | Tomoro Hishiki, Tadashi Matsunaga, Fumiaki Sasaki, Michihiro Yano, Kohmei Ida, Hiroshi Horie, Satoshi Kondo, Ken-Ichiro Watanabe, Takaharu Oue, Tatsuro Tajiri, Arata Kamimatsuse, Naomi Ohnuma, Eiso Hiyama |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 27
Issue 1
Pg. 1-8
(Jan 2011)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 20922397
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Alkylating
- Antineoplastic Agents, Phytogenic
- Etoposide
- Doxorubicin
- Carboplatin
- pirarubicin
- Cisplatin
- Ifosfamide
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Topics |
- Adolescent
- Antineoplastic Agents, Alkylating
(administration & dosage, therapeutic use)
- Antineoplastic Agents, Phytogenic
(administration & dosage, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Carboplatin
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Cisplatin
(administration & dosage, therapeutic use)
- Doxorubicin
(administration & dosage, analogs & derivatives, therapeutic use)
- Etoposide
(administration & dosage, therapeutic use)
- Female
- Hematopoietic Stem Cell Transplantation
- Hepatoblastoma
(drug therapy, surgery)
- Humans
- Ifosfamide
(administration & dosage, therapeutic use)
- Infant
- Infant, Newborn
- Japan
- Liver
(drug effects, surgery)
- Liver Neoplasms
(drug therapy, surgery)
- Male
- Survival Analysis
- Treatment Outcome
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