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Inhibition of posterior capsule opacification by 5-fluorouracil in rabbits.

Abstract
An extracapsular cataract extraction was performed on both eyes of 24 rabbits. Irrigation for 10 min of the capsular bag of the left (test) eye with 8-12 cm3 of 1 litre of BSS-plus to which had been added 50 mg of 5-fluorouracil significantly inhibited proliferation of the anterior capsular epithelium as compared with the right (control) eyes identically treated except for the omission of 5-fluorouracil (p less than 0.001). Corneal endothelial counts did not differ significantly. A reduction in opacification of the posterior capsule is expected from 5-fluorouracil treatment.
AuthorsJ M Ruíz, M Medrano, J L Alió
JournalOphthalmic research (Ophthalmic Res) Vol. 22 Issue 4 Pg. 201-8 ( 1990) ISSN: 0030-3747 [Print] Switzerland
PMID2089339 (Publication Type: Journal Article)
Chemical References
  • Fluorouracil
Topics
  • Animals
  • Cataract (prevention & control)
  • Cataract Extraction
  • Cell Count (drug effects)
  • Cell Division (drug effects)
  • Endothelium, Corneal (drug effects)
  • Epithelium (drug effects)
  • Fluorouracil (therapeutic use, toxicity)
  • Lens Capsule, Crystalline (drug effects)
  • Rabbits

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