Clinical application of therapies targeting VEGF.

Abstract

This year's Lasker DeBakey Clinical Research Award goes to Napoleone Ferrara for the discovery of vascular endothelial growth factor (VEGF) as a major mediator of angiogenesis and for the development of an effective anti-VEGF therapy for wet macular degeneration, a leading cause of blindness in the elderly.

• Authors: George D Yancopoulos
• Journal: Cell (Cell) Vol. 143 Issue 1 Pg. 13-6 (Oct 01 2010) ISSN: 1097-4172 [Electronic] United States
• PMID: 20887885 (Publication Type: Biography, Historical Article, Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Angiogenesis Inhibitors
• Vascular Endothelial Growth Factor A

Topics

• Aged
• Angiogenesis Inhibitors (history, therapeutic use)
• Awards and Prizes
• Eye (blood supply)
• History, 20th Century
• History, 21st Century
• Humans
• Neoplasms (drug therapy)
• Neovascularization, Pathologic (prevention & control)
• United States
• Vascular Endothelial Growth Factor A (antagonists & inhibitors, genetics)
• Wet Macular Degeneration (drug therapy)