[Leukocyte nitric oxide status in patients with chronic recurrent furunculosis].

Abstract

The basal and in vitro pyrogenal-stimulated nitric oxide-producing capabilities of leukocytes versus their oxygen-producing and phagocytic activity were studied in patients with chronic recurrent furunculosis during remission (n=62) and exacerbation (n=12). The basal nitric oxide-producing activity of leukocytes was found to be similar. The stimulated leukocyte cultures from the patients showed mainly a perverted reaction--suppression of nitric oxide production instead of its increase detectable in donors. A direct correlation was found between the nitric oxide-producing activity of leukocytes and the results of HCT test in healthy individuals and patients during exacerbation rather than remission.

• Authors: I A Novikova, A V Gomoliako
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 8 Pg. 34-6 (Aug 2010) ISSN: 0869-2084 [Print] Russia (Federation)
• PMID: 20886717 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lipopolysaccharides
• Reactive Oxygen Species
• pyrogenal
• Nitric Oxide

Topics

• Adolescent
• Adult
• Case-Control Studies
• Cells, Cultured
• Female
• Furunculosis (blood, metabolism, microbiology)
• Humans
• Leukocytes (drug effects, immunology, metabolism)
• Lipopolysaccharides (pharmacology)
• Male
• Middle Aged
• Neutrophils (immunology, metabolism)
• Nitric Oxide (biosynthesis)
• Phagocytosis (drug effects)
• Reactive Oxygen Species (metabolism)
• Recurrence
• Staphylococcal Infections (blood, metabolism, microbiology)
• Staphylococcus aureus (growth & development)
• Young Adult