Effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in patients on chronic hemodialysis.

Abstract

AIM:

We investigated the effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in hyperlipidemic endstage renal disease patients on chronic hemodialysis (HD).

METHODS:

In 25 hyperlipidemic HD patients who received 10 mg of simvastatin for 6 months and another 25 controls, the extended lipid profile and serum hsIL-6, MCP-1, sICAM-1, sVCAM-1, and sE-selectin, plasma oxLDL, and serum sFas and sFasL levels were determined at baseline, 3 months and 6 months. In 18 patients of the simvastatin group, the expression of CD14, CD16, CD62L and CD64 on monocyfes was determined with flow cytometry.

RESULT:

Simvastatin treatment resulted in significant reductions in serum lipid levels at 3 months and beyond, compared to at baseline. Moreover, at 6 months, simvastatin caused a significant reduction in CRP (p < 0.001), which correlated to the decrease in total and LDL cholesterol levels, as well as a significant reduction in IL-6 (p=0.001), sICAM-1 (p < 0.001), sVCAM-1 (p < 0.001), oxLDL (p=0.001), sFas (p=0.02) and CD14 expression (p < 0.001), compared to baseline values. No significant changes in the controls were noticed during the study.

CONCLUSION:

In conclusion, in hyperlipidemic HD patients, simvastatin treatment resulted in a significant reduction in markers of endothelial dysfunction, inflammation, oxidative stress, endothelial cell apoptosis and peripheral blood monocyte stimulation. The reduction in CRP appears to be related to the lipid-lowering effects of simvastatin.

• Authors: Dimitrios Kirmizis, Aikaterini Papagianni, Fani Dogrammatzi, Lemonia Skoura, Anna-Maria Belechri, Efstathios Alexopoulos, Georgios Efstratiadis, Dimitrios Memmos
• Journal: Journal of atherosclerosis and thrombosis (J Atheroscler Thromb) Vol. 17 Issue 12 Pg. 1256-65 (Dec 26 2010) ISSN: 1880-3873 [Electronic] Japan
• PMID: 20885069 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Hypolipidemic Agents
• Lipids
• C-Reactive Protein
• Simvastatin

Topics

• Apoptosis (drug effects)
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Case-Control Studies
• Endothelial Cells (drug effects)
• Humans
• Hypolipidemic Agents (pharmacology)
• Inflammation (drug therapy)
• Kidney Failure, Chronic (drug therapy, pathology, therapy)
• Lipids (blood)
• Monocytes (drug effects)
• Oxidative Stress (drug effects)
• Renal Dialysis
• Simvastatin (pharmacology)