Abstract | OBJECTIVE: DESIGN: Prospective, randomized, controlled study. SETTING: The reproductive endocrinology unit of a tertiary, research and education hospital. PATIENT(S): Forty women with severe endometriosis (revised The American Fertility Society [AFS] classification >40) and endometriosis-related CPP and control groups were enrolled in the study. INTERVENTION(S): The patients were treated with either LNG-IUS (n = 20) or GnRH-a (n = 20). The GnRH-a dose was repeated every 4 weeks for 24 weeks. MAIN OUTCOME MEASURE(S): Scores of CPP were evaluated using a visual analogue scale (VAS) and total endometriosis severity profile (TESP). RESULT(S): The TESP score decreased in the LNG-IUS group at first, third, and sixth month follow-up visits, whereas at the 12th month follow-up visit, the TESP scores were increased to values similar to pretreatment values. Although the VAS score had no significant alteration during the follow-up period in the LNG-IUS group, the GnRH-a group showed a significant decrease in the VAS score and TESP score at the end of 1 year. The LNG-IUS treatment showed a lower patient satisfaction. CONCLUSION(S): Both treatment modalities showed comparable effectiveness in the treatment of CPP-related endometriosis.
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Authors | Yesim Bayoglu Tekin, Berna Dilbaz, Sadiman Kiykac Altinbas, Serdar Dilbaz |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 95
Issue 2
Pg. 492-6
(Feb 2011)
ISSN: 1556-5653 [Electronic] United States |
PMID | 20883991
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Delayed-Action Preparations
- Fertility Agents, Female
- Goserelin
- Gonadotropin-Releasing Hormone
- Levonorgestrel
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Topics |
- Adult
- Chronic Disease
- Delayed-Action Preparations
- Endometriosis
(complications, drug therapy, surgery)
- Female
- Fertility Agents, Female
(administration & dosage)
- Follow-Up Studies
- Gonadotropin-Releasing Hormone
(administration & dosage, adverse effects, analogs & derivatives)
- Goserelin
(administration & dosage)
- Gynecologic Surgical Procedures
(adverse effects, rehabilitation)
- Humans
- Intrauterine Devices, Medicated
(adverse effects)
- Levonorgestrel
(administration & dosage, adverse effects)
- Pain, Postoperative
(drug therapy)
- Pelvic Pain
(drug therapy, etiology)
- Treatment Outcome
- Uterine Diseases
(complications, drug therapy, surgery)
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