HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective.

Abstract
The use of reliable biomarkers is becoming increasingly important for the improved management of patients with acute and chronic kidney diseases. Recent developments have identified a number of novel biomarkers in serum or urine that can determine the potential risk of kidney damage, distinguish different types of renal injury, predict the progression of disease and have the potential to assess the efficacy of therapeutic intervention. Some of these biomarkers can be used independently while others are more beneficial when used in combination with knowledge of other clinical risk factors. Advances in gene expression analysis, chromatography, mass spectrometry and the development of sensitive enzyme-linked immunosorbent assays have facilitated accurate quantification of many biomarkers. This review primarily focuses on describing new and established biomarkers, which identify and measure the various pathophysiological processes that promote kidney disease. It provides an overview of some of the different classes of renal biomarkers that can be assessed in serum/plasma and urine, including markers of renal function, oxidative stress, structural and cellular injury, immune responses and fibrosis. However, it does not explore the current status of these biomarkers in terms of their clinical validation.
AuthorsGreg H Tesch
JournalNephrology (Carlton, Vic.) (Nephrology (Carlton)) Vol. 15 Issue 6 Pg. 609-16 (Sep 2010) ISSN: 1440-1797 [Electronic] Australia
PMID20883281 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright© 2010 The Author. Nephrology © 2010 Asian Pacific Society of Nephrology.
Chemical References
  • Biomarkers
Topics
  • Animals
  • Biomarkers (blood, urine)
  • Fibrosis
  • Humans
  • Kidney (immunology, metabolism, pathology, physiopathology)
  • Kidney Diseases (blood, diagnosis, physiopathology, urine)
  • Kidney Function Tests
  • Oxidative Stress
  • Predictive Value of Tests
  • Prognosis
  • Proteomics
  • Reproducibility of Results
  • Severity of Illness Index

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: