HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of hippocampal high-frequency electrical stimulation in memory formation and their association with amino acid tissue content and release in normal rats.

Abstract
Hippocampal high frequency electrical stimulation (HFS) at 130 Hz has been proposed as a therapeutical strategy to control neurological disorders such as intractable temporal lobe epilepsy (TLE). This study was carried out to determine the effects of hippocampal HFS on the memory process and the probable involvement of amino acids. Using the autoshaping task, we found that animals receiving hippocampal HFS showed augmented short-term, but not long-term memory formation, an effect blocked by bicuculline pretreatment and associated with enhanced tissue levels of amino acids in hippocampus. In addition, microdialysis experiments revealed high extracellular levels of glutamate, aspartate, glycine, taurine, and alanine during the application of hippocampal HFS. In contrast, GABA release augmented during HFS and remained elevated for more than 1 h after the stimulation was ended. HFS had minimal effects on glutamine release. The present results suggest that HFS has an activating effect on specific amino acids in normal hippocampus that may be involved in the enhanced short-term memory formation. These data further provide experimental support for the concept that hippocampus may be a promising target for focal stimulation to treat intractable seizures in humans.
AuthorsHiram Luna-Munguía, Alfredo Meneses, Fernando Peña-Ortega, Andres Gaona, Luisa Rocha
JournalHippocampus (Hippocampus) Vol. 22 Issue 1 Pg. 98-105 (Jan 2012) ISSN: 1098-1063 [Electronic] United States
PMID20882549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Wiley Periodicals, Inc., Inc.
Chemical References
  • Amino Acids
Topics
  • Amino Acids (metabolism)
  • Animals
  • Brain Chemistry (drug effects, physiology)
  • Electric Stimulation (methods)
  • Extracellular Fluid (metabolism)
  • Hippocampus (drug effects, metabolism)
  • Male
  • Memory, Short-Term (drug effects, physiology)
  • Rats
  • Rats, Wistar
  • Tissue Distribution (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: