[Effect of omega-3 acids on clinical evolution, plasma inflammatory biomarkers and B-type natriuretic peptide levels in patients with coronary heart disease].

Abstract

BACKGROUND AND OBJECTIVE:

The consumption of fish has been associated with a minor risk of cardiovascular mortality.

PATIENTS AND METHODS:

Thirty-one patients with clinical and angiographic evidence of coronary illness and no data of heart failure were followed up. One gram per day of omega-3-acid ethyl esters was added to their usual cardiologic treatment. Demographic, clinical and analytical data (lipid, ESR, CRP, lipoprotein[a], fibrinogen, and BNP levels) were evaluated at the beginning and at 9 months.

RESULTS:

Six patients had cardiologic events in the follow up although none presented acute coronary syndrome. Significant differences were seen in HDL cholesterol (mg/dL) (38,5[9,6] vs. 42,1 (11,0), p=0,000), hemoglobin (g/dL) (13,2 [1,7] vs. 13,9 (1,7), p=0,009) and pro-BNP (pg/dL) (745,5 [1,035,7] vs. 235,8 [194,0], p=0,008) levels. No significant differences existed either in the inflammatory parameters or in total cholesterol, LDL cholesterol and triglycerides.

CONCLUSION:

One gram day of omega-3-acid ethyl esters added to the usual cardiologic treatment in patients with coronary heart disease improves pro BNP levels of patients with preserved left ventricular function without modifying serum inflammatory parameters.

• Authors: Efrén Martínez-Quintana, Fayna Rodríguez-González, Estrella Torres-Fuentes, Laura López-Ríos, Vicente Nieto-Lago
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 136 Issue 13 Pg. 574-7 (May 14 2011) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Efecto de los ácidos grasos omega-3 en la evolución clínica, biomarcadores inflamatorios y el péptido natriurético cerebral de pacientes con cardiopatía isquémica.
• PMID: 20880559 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2010 Elsevier España, S.L. All rights reserved.

Chemical References

• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL
• Fatty Acids, Omega-3
• Triglycerides
• Natriuretic Peptide, Brain

Topics

• Aged
• Biomarkers (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Disease (blood, complications, drug therapy)
• Drug Administration Schedule
• Fatty Acids, Omega-3 (administration & dosage, therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Triglycerides (blood)